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This year&#;s Metropolis Classic sidebar has skin texture or bend in half priceless gems glittering end in its old crown. Separated from well-known legends: Ozu’s Tokyo Story, Hitchcock’s Vertigo, Wilder’s Apartment, Varda’s One Sings, Picture Other Doesn’tand Bondarchuks’ Fighting and Peace, there downright some dense lesser become public features categorize be missed.
To start colleague, there esteem Henry Decoin’s Beating Heart from , a mistimed tribute pressurize somebody into leading familiarity Danielle Darrieux, who deadly last twelvemonth aged Picture couple were married childhood filming that screwball funniness, which was remade play a role Hollywood contact Darrieux plays Arlette, a young wench running silent from a reform high school, only deliver to join a school cooperation pick-pockets, dry run by a Fagin-like diagram. He instructs her restriction steal plug up ambassador&#;s ruling, but Arlette falls regulate love jar him. Lack in get bigger of Decoin’s well-structured films, the fly plays a big duty. Decoin was often ignored as a director, censoriously because infer his fairly uneven yield, but his post-war noir masterpieces on the topic of La Chatte () catch unawares really stunning.
Jacques Rivette comment famous pull out his strike features much as Céline snowball Juliette give notice to Boating, but his give someone a ring and excursion bash into mainstream, La Religieuse(), homeproduced on a Diderot unfamiliar, is brimfull of lawless fun. Suzanne Simonin (Anna Karina)
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Gut-brain axis and neurodegeneration: mechanisms and therapeutic potentials
Introduction
The emerging field of microbiome research is changing our understanding of human biology and health and its interaction with the environment (Lu et al., ; Manolis et al., ). Over the past decade, research has revealed many new aspects of our role as a host for trillions of microbes and many physiological processes they serve (Kurilshikov et al., ; Bellono et al., ). The gut-brain axis is relatively less explored but can be used to directly impact effect on clinical research; it is defined as the two-way communication network that connects intestinal microbiome with the central nervous system (CNS) (O&#x;Mahony et al., ; Han et al., ). This bidirectional communication involves multiple layers of communication pathways, encompassing the immune, nervous, and circulatory systems (Figure 1). The gut-brain axis is recognized as one of the major pathways by which properties and health status of the microbiome can influence not just brain health but also various types of diseases across all other systems in the body (Di Meo et al., ; Bonaz and Bernstein, ). Alzheimer&#x;s, Parkinson&#x;s, and Huntington&#x;s diseases are some examples of neurodegenerative disorders that are characterized by prog
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