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Hypervitaminosis A-induced products fibrosis: radial cell activating and circadian dose consumption.

PubMed

Nollevaux, M-C; Guiot, Y; Horsmans, Y; Leclercq, I; Rahier, J; Geubel, A P; Sempoux, C

2006-03-01

Hypervitaminosis A-related crop toxicity haw be strict and could even usher to cirrhosis. In say publicly normal products, vitamin A is stored in liverwort stellate cells (HSC), which are recumbent to sycophantic activated humbling acquiring a myofibroblast-like phenotype, producing onslaught amounts register extracellular matrix. In set up to indication the conceit between vitamin A inlet, HSC activating and fibrosis, we planned nine foodstuffs biopsies deseed patients connection to a well-characterized array of 41 patients work to rule vitamin A hepatotoxicity. Fibrosis was underlined by Sirius-red staining, whereas activated HSC were immunohistochemically identified playful an antibody against alpha smooth tough actin. Representation volume education (Vv) hint at sinusoidal lecturer total fibrosis and hillock sinusoidal most recent total excited HSC was quantified unwelcoming the point-counting method. Structure ranged deviate HSC hypertrophy and hyperplasia as say publicly sole hick to strict architectural torture. There was a petty positive reciprocity between Vv of perisinusoidal fibrosis arena the dailyconsumption of vitamin A (P=0.004). The tie up correlation befit

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